Urine (30% to 40% unchanged ~50% as metabolites) Time to Peak Hepatic via oxidation, deamination, and CYP2D6 Excretion Oral: Immediate-release tablet: V d: 3 to 4 L/kg (de la Torre 2004) Metabolism Immediate-release orally-disintegrating tablet: Evekeo ODT: C max and AUC comparable to equivalent immediate-release dose Distribution Immediate-release tablet: Rapid (de la Torre 2004) Pharmacokinetics/Pharmacodynamics Absorption The anorexigenic effect is probably secondary to the CNS-stimulating effect the site of action is probably the hypothalamic feeding center. A less significant mechanism may include their ability to block the reuptake of catecholamines by competitive inhibition. Tablet Extended Release Disintegrating, Oral, as base:Īdzenys XR-ODT: 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg Pharmacology Mechanism of ActionĪmphetamines are noncatecholamine sympathomimetic amines that promote release of catecholamines (primarily dopamine and norepinephrine) from their storage sites in the presynaptic nerve terminals. Suspension Extended Release, Oral, as base:ĭyanavel XR: 2.5 mg/mL (464 mL) Įvekeo: 10 mg Įvekeo: 10 mg = Discontinued productĪdzenys ER: 1.25 mg/mL (450 mL) Excipient information presented when available (limited, particularly for generics) consult specific product labeling.
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